Application-of-the-proposed-sydney-system-in-reporting-of-the-lymph-node-cytopathology—a-retrospective-study

Introduction: Fine needle aspiration cytology (FNAC) is a widely accepted first line of investigation to diagnose the cause of lymphadenopathy. A standardized categorization and reporting system for lymph node cytology was proposed in 20th International Congress of Cytology at Sydney which consisted of 5 categories (L1, L2, L3, L4, L5) with management recommendations for each. Aims and Objective: To review the application of the Sydney system in achieving a uniform standardized approach for classifying and reporting lymph node cytology and to assess the risk of malignancy (ROM) for each category. : A 2 year single institute retrospective study. Clinical details were collectedMaterials and Methods from the patient records and cytology smears were reviewed by 2 cyto-pathologists as per the Sydney system. Histological correlation was done wherever possible. Statistical analysis was performed. 437 cases were re-Results: evaluated, with mean age of 39.66 years, slight male preponderance and cervical lymph node being the most common site. L2/Benign was the most common category with reactive lymphoid hyperplasia being the most common diagnosis and metastatic squamous cell carcinoma was the most common L5/malignant diagnosis. Histopathological correlation was available for 40 (9.1%) cases and the highest calculated risk of malignancy (ROM) was for L4 and L5 categories (100% each). The diagnostic accuracy of the proposed Sydney system in our study was 96.66%. TheConclusion: proposed Sydney system improves the diagnostic accuracy and standardizes the reporting of lymph node cyto- pathology. It improves the patient care by giving management recommendation to the clinicians.

Histomorphological-study-of-mucormycosis-in-covid19-patients-with-special-reference-to-rhinoorbital-region-in-a-tertiary-care-center

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019 in Wuhan city, Hubei province, China. The patients with comorbid conditions like diabetes mellitus, lung disease are prone to a wide range of viral, bacterial and fungal infections. Aims And Objectives 1. To know the frequency of mucormycosis in Covid-19 patients. 2. To describe histomorphological pattern of mucormycosis and other fungal infections in Covid-19 patients. Materials And Methods: A prospective study was conducted from May 2021 to August 2021 for four month period with a sample size of 57 at a tertiary care hospital in south India. All the patients who were diagnosed with and or recovered from COVID-19 infection and came back with the fungal infection symptoms were subjected to surgical debridement were included in the study. All the demographic and clinical data were obtained from requests. In the presentResults: study we got 57 cases of covid-19 patient with suspected fungal infections.We examined the biopsy taken from different sites of rhinoorbital area with H&E and GMS stain. Out of 57 cases 36 cases were found to be having mucormycosis. Conclusion: Since Covid-19 is a risk for many opportunistic infections, its association with invasive fungal infection is dangerous and must be given serious consideration